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Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer

1 Dec 2014

Abstract excerpt

BACKGROUND: Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation. However, the function of APP in the pathogenesis of breast cancer has not previously been determined. In this...

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PMID: 25491510
DOI: 10.1186/1471-2407-14-928

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