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Article

Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin.

Journal of natural products - 26 Aug 2016

Kim Eunji, Song Myoung Chong, Kim Myoun Su, Beom Ji Yoon, Lee Eun Yeol, Kim Dong-Myung, Nam Sang-Jip, Yoon Yeo Joon

Abstract excerpt

The S-adenosyl-l-methionine-dependent O-methyltransferases TylE and TylF catalyze the last two methylation reactions in the tylosin biosynthetic pathway of Streptomyces fradiae. It has long been known that the TylE-catalyzed C2‴-O-methylation of the 6-deoxy-d-allose bound to demethylmacrocin or demethyllactenocin precedes the TylF-catalyzed C3‴-O-methylation of the d-javose (C2‴-O-methylated 6-deoxy-d-allose)...

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PMID: 27453999
DOI: 10.1021/acs.jnatprod.6b00267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin.PMID 27453999Read ↗

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