Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of mutations in regulatory genes of Tyl cluster leading to overexpression of tylosin in mutant γ-1 of Streptomyces fradiae NRRL-2702.

Applied microbiology and biotechnology - 1 Jan 2014

Khaliq Shazia, Ghauri Muhammad A, Akhtar Kalsoom

Abstract excerpt

Tylosin is a veterinary antibiotic and is commercially produced using Streptomyces fradiae. Previously, we developed a mutant γ-1 of S. fradiae NRRL-2702 with a 6.87-fold increase in tylosin yield as compared with the wild-type strain through irradiation mutagenesis. The present studies were conducted to explore mutational changes in regulatory genes (TylQ, TylP, TylS, TylR, and TylT) of Tyl cluster that may lead...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Biosynthetic Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Expression Profiling

Share to Genes, Regulator

Share to Multigene Family

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Streptomyces

Source

Identifiers

PMID: 24270892
DOI: 10.1007/s00253-013-5317-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of mutations in regulatory genes of Tyl cluster leading to overexpression of tylosin in mutant γ-1 of Streptomyces fradiae NRRL-2702.PMID 24270892Read ↗

The tylosin-biosynthetic genes of Streptomyces fradiaeSemantic proximity Read ↗

Positive control of tylosin biosynthesis: pivotal role of TylR.Semantic proximity Read ↗

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.Semantic proximity Read ↗

Regulation of tylosin biosynthesis involving 'SARP-helper' activity.Semantic proximity Read ↗

Analysis of multidrug resistance in Streptococcus suis ATCC 700794 under tylosin stressSemantic proximity Read ↗

The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.Semantic proximity Read ↗

Functional insights into the mode of DNA and ligand binding of the TetR family regulator TylP from Streptomyces fradiae.Semantic proximity Read ↗

Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.Semantic proximity Read ↗

The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin The GenBank accession number for the sequence determined in this work is AF147704.Semantic proximity Read ↗

Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes.Semantic proximity Read ↗

Production of tylosin in solid-state fermentation by Streptomyces fradiae NRRL-2702 and its gamma-irradiated mutant (gamma-1).Semantic proximity Read ↗

Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.