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Article

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin.

Antimicrobial agents and chemotherapy - 1 Aug 1990

Huber M L, Paschal J W, Leeds J P, Kirst H A, Wind J A, Miller F D, Turner J R

Abstract excerpt

Three branched-chain fatty acids (7-hydroxy-4,6-dimethylnona-2,4-dienoic acid [compound 1], its 7-epimer [compound 2], and 7-keto-4,6-dimethylnona-2,4-dienoic acid [compound 3]) and a ketone (9-hydroxy-6,8-dimethylundeca-4,6-dien-3-one [compound 4]) were isolated from the culture broth of mutants of Streptomyces fradiae which were blocked in the biosynthesis of the macrolide antibiotic tylosin. Two phenotypic...

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Identifiers

PMID: 2221862
DOI: 10.1128/AAC.34.8.1535
PMCID: PMC171868

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Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin.PMID 2221862Read ↗

The tylosin-biosynthetic genes of Streptomyces fradiaeSemantic proximity Read ↗

The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.Semantic proximity Read ↗

Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin.Semantic proximity Read ↗

The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin The GenBank accession number for the sequence determined in this work is AF147704.Semantic proximity Read ↗

Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes.Semantic proximity Read ↗

Characterization of mutations in regulatory genes of Tyl cluster leading to overexpression of tylosin in mutant γ-1 of Streptomyces fradiae NRRL-2702.Semantic proximity Read ↗

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.Semantic proximity Read ↗

Positive control of tylosin biosynthesis: pivotal role of TylR.Semantic proximity Read ↗

Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae.Semantic proximity Read ↗

Regulation of tylosin biosynthesis involving 'SARP-helper' activity.Semantic proximity Read ↗

Mutational biosynthesis of neomycin analogs by a mutant of neomycin-producing Streptomyces fradiae.Semantic proximity Read ↗

Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.Semantic proximity Read ↗

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