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Article

The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.

Journal of natural products - 1 Jan 2000

Cox K L, Fishman S E, Larson J L, Stanzak R, Reynolds P A, Yeh W K, van Frank R M, Birmingham V A, Hershberger C L, Seno E T

Abstract excerpt

A substantial amount of information on the biosynthesis of tylosin has been obtained over the past ten years. Physiological studies and experiments with tylosin-blocked (tyl) mutants have suggested the probable pathway by which tylactone is converted to tylosin. The development of recombinant DNA methodology for streptomycetes in general, and for Streptomyces fradiae in particular, has allowed us to apply gene...

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PMID: 3572425
DOI: 10.1021/np50048a002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.PMID 3572425Read ↗

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