The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.

doi:10.1021/np50048a002

Article

The use of recombinant DNA techniques to study tylosin biosynthesis and resistance in Streptomyces fradiae.

Journal of natural products - 1 Jan 2000

Cox K L, Fishman S E, Larson J L, Stanzak R, Reynolds P A, Yeh W K, van Frank R M, Birmingham V A, Hershberger C L, Seno E T

Abstract excerpt

A substantial amount of information on the biosynthesis of tylosin has been obtained over the past ten years. Physiological studies and experiments with tylosin-blocked (tyl) mutants have suggested the probable pathway by which tylactone is converted to tylosin. The development of recombinant DNA...

Topics

DNA, Bacterial
DNA, Recombinant
Drug Resistance, Microbial
Leucomycins
Phenotype
Plasmids
Streptomyces

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