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Article

LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis.

Chembiochem : a European journal of chemical biology - 1 Aug 2005

Luzhetskyy Andriy, Taguchi Takaaki, Fedoryshyn Marta, Dürr Clemens, Wohlert Sven-Eric, Novikov Volodymyr, Bechthold Andreas

Abstract excerpt

The glycosyltransferase LanGT2 is involved in the biosynthesis of the hexasaccharide side chain of the angucyclic antibiotic landomycin A. Its function was elucidated by targeted gene inactivation of lanGT2. The main metabolite of the obtained mutant was identified as tetrangulol (4), the progenitor of the landomycin aglycon (7). The lack of the sugar side chain indicates that LanGT2 catalyzes the priming...

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PMID: 15977274
DOI: 10.1002/cbic.200500018

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