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Article

Positive control of tylosin biosynthesis: pivotal role of TylR.

Molecular microbiology - 1 Dec 2004

Stratigopoulos George, Bate Neil, Cundliffe Eric

Abstract excerpt

Control of tylosin production in Streptomyces fradiae features interplay between a repressor, TylQ, and an activator, TylS, during regulation of tylR. The latter encodes a pathway-specific activator that controls most of the tylosin-biosynthetic (tyl) genes that are subject to regulation. This was established by targeted gene disruption applied separately to tylR and tylS together with transcript analysis...

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Identifiers

PMID: 15554972
DOI: 10.1111/j.1365-2958.2004.04347.x

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