Article
A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.
Journal of molecular biology - 21 Oct 2011
Akey David L, Li Shengying, Konwerski Jamie R, Confer Laura A, Bernard Steffen M, Anzai Yojiro, Kato Fumio, Sherman David H, Smith Janet L
Abstract excerpt
O-linked methylation of sugar substituents is a common modification in the biosynthesis of many natural products and is catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyltransferases (MTs). Mycinamicins, potent antibiotics from Micromonospora griseorubida, can be methylated at two positions on a 6-deoxyallose substituent. The first methylation is catalyzed by MycE, a SAM-...
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