Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-Specific Quantification of Structural Variations in Cancer Genomes.

Cell systems - 1 Jul 2016

Li Yang, Zhou Shiguo, Schwartz David C, Ma Jian

Abstract excerpt

Aneuploidy and structural variations (SVs) generate cancer genomes containing a mixture of rearranged genomic segments with extensive somatic copy number alterations. However, existing methods can identify either SVs or allele-specific copy number alterations but not both simultaneously, which provides a limited view of cancer genome structure. Here, we introduce Weaver, an algorithm for the quantification and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to DNA Copy Number Variations
Share to Genomic Structural Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to HeLa Cells

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasms

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 27453446
DOI: 10.1016/j.cels.2016.05.007
PMCID: PMC4965314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-Specific Quantification of Structural Variations in Cancer Genomes.PMID 27453446Read ↗

Allele-Specific Quantification of Structural Variations in Cancer GenomesSemantic proximity Read ↗

Toward Recovering Allele-specific Cancer Genome Graphs.Semantic proximity Read ↗

SCONCE: a method for profiling copy number alterations in cancer evolution using single-cell whole genome sequencingSemantic proximity Read ↗

Characterizing the allele- and haplotype-specific copy number landscape of cancer genomes at single-cell resolution with CHISELSemantic proximity Read ↗

Integrative detection and analysis of structural variation in cancer genomes.Semantic proximity Read ↗

Reconstructing cancer genomes from paired-end sequencing data.Semantic proximity Read ↗

Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL.Semantic proximity Read ↗

FACETS: Fraction and Allele-Specific Copy Number Estimates from Tumor Sequencing.Semantic proximity Read ↗

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing.Semantic proximity Read ↗

Alleloscope: Integrative single cell analysis of allele-specific copy number alterations and chromatin accessibility in cancerSemantic proximity Read ↗

Evolutionary tracking of cancer haplotypes at single-cell resolutionSemantic proximity Read ↗

Wakhan: reconstruction of chromosome-scale copy number profiles of tumor genomes with long-read sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.