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Article

Toward Recovering Allele-specific Cancer Genome Graphs.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jul 2018

Rajaraman Ashok, Ma Jian

Abstract excerpt

Integrated analysis of structural variants (SVs) and copy number alterations in aneuploid cancer genomes is key to understanding tumor genome complexity. A recently developed algorithm, Weaver, can estimate, for the first time, allele-specific copy number of SVs and their interconnectivity in aneuploid cancer genomes. However, one major limitation is that not all SVs identified by Weaver are phased. In this...

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Identifiers

PMID: 29658776
DOI: 10.1089/cmb.2018.0022
PMCID: PMC6067097

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