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Article

Reconstructing cancer genomes from paired-end sequencing data.

BMC bioinformatics - 19 Apr 2012

Oesper Layla, Ritz Anna, Aerni Sarah J, Drebin Ryan, Raphael Benjamin J

Abstract excerpt

BACKGROUND: A cancer genome is derived from the germline genome through a series of somatic mutations. Somatic structural variants - including duplications, deletions, inversions, translocations, and other rearrangements - result in a cancer genome that is a scrambling of intervals, or "blocks" of the germline genome sequence. We present an efficient algorithm for reconstructing the block organization of a cancer...

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Identifiers

PMID: 22537039
DOI: 10.1186/1471-2105-13-S6-S10
PMCID: PMC3358655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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