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Article

Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders.

Journal of affective disorders - 15 May 2015

Pandolfo G, Gugliandolo A, Gangemi C, Arrigo R, Currò M, La Ciura G, Muscatello M R A, Bruno A, Zoccali R, Caccamo D

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) and bipolar disorder (BD) are the two most common mood disorders. Given the recognized involvement of catecholamines in depression, genetic research focused on the evaluation of polymorphisms in genes coding for proteins that regulate neurotransmitter release, transport and degradation. Here we aimed at evaluating the distribution of two genetic variants of...

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Source

Identifiers

PMID: 25766270
DOI: 10.1016/j.jad.2015.02.016

Genes

COMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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