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Article

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis.

PloS one - 1 Jan 2022

Meng Xinyao, Zheng Ji-Long, Sun Mao-Ling, Lai Hai-Yun, Wang Bao-Jie, Yao Jun, Wang Hongbo

Abstract excerpt

Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate the relationship between MTHFR gene polymorphisms (677C>T and 1298A>C) and the occurrence of ADHD, BD and SCZ....

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Identifiers

PMID: 35834596
DOI: 10.1371/journal.pone.0271170
PMCID: PMC9282595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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