Article
Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia.
Neuroscience letters - 12 Jun 2006
Kempisty Bartosz, Mostowska Adrianna, Górska Ilona, Łuczak Marta, Czerski Piotr, Szczepankiewicz Aleksandra, Hauser Joanna, Jagodziński Paweł P
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism 677C>T has been shown to be a risk factor for psychiatric disorders. We investigated the genotype and allelic frequencies of MTHFR 677C>T polymorphism in the group of patients with bipolar disorder type I (BDI) (n=200) and schizophrenia (n=200), and in the control group (n=300). Odds ratio (OR) for patients with BD and schizophrenia with 677T allele...
Topics
- Adult
- Bipolar Disorder
- Comorbidity
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)