Article
Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016
Meiler Svenja, Smeets Esther, Winkels Holger, Shami Annelie, Pascutti Maria Fernanda, Nolte Martijn A, Beckers Linda, Weber Christian, Gerdes Norbert, Lutgens Esther
Abstract excerpt
OBJECTIVE: Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is expressed on CD4(+) effector memory T cells and regulatory T cells; however, its role on these functionally opposing cell types in atherosclerosis is not fully understood. APPROACH AND RESULTS: Low-density lipoprotein receptor-deficient mice (Ldlr(-/-)) were lethally irradiated and reconstituted with either bone...
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