Article

T-cell Abca1 and Abcg1 cholesterol efflux pathways suppress T-cell apoptosis and senescence and increase atherosclerosis in middle-aged <i>Ldlr</i> <sup>-/-</sup> mice

2022-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T-cells accumulate cholesterol, which could lead to a pro-inflammatory phenotype. However, the role of cholesterol efflux pathways mediated by ATP-binding cassette A1 and G1 (ABCA1/ABCG1) in T-cell-dependent age-related inflammation and atherosclerosis remains poorly understood. In this study, we gene...

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Literature Corpus work: 4e4c407a-1eb7-5500-9b39-1ad8620622e5
DOI: 10.1101/2022.04.10.487770

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T-cell Abca1 and Abcg1 cholesterol efflux pathways suppress T-cell apoptosis and senescence and increase atherosclerosis in middle-aged <i>Ldlr</i> <sup>-/-</sup> miceDOI 10.1101/2022.04.10.487770Read

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