Article
CD8(+)CD25(+) T cells reduce atherosclerosis in apoE(-/-) mice.
Biochemical and biophysical research communications - 17 Jan 2014
Zhou Jianchang, Dimayuga Paul C, Zhao Xiaoning, Yano Juliana, Lio Wai Man, Trinidad Portia, Honjo Tomoyuki, Cercek Bojan, Shah Prediman K, Chyu Kuang-Yuh
Abstract excerpt
BACKGROUND: It is increasingly evident that CD8(+) T cells are involved in atherosclerosis but the specific subtypes have yet to be defined. CD8(+)CD25(+) T cells exert suppressive effects on immune signaling and modulate experimental autoimmune disorders but their role in atherosclerosis remains to be determined. The phenotype and functional role of CD8(+)CD25(+) T cells in experimental atherosclerosis were...
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