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Article

Prognostic significance of thymidylate synthase polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Apr 2013

Arrazubi V, Suárez J, Guerrero D, Gómez M, Viúdez A, Arias F, Balén E, Vera R

Abstract excerpt

AIM: There is a lack of prognostic factors of preoperative chemoradiation for locally advanced rectal cancer. Thymidylate synthase (TS) is the most important target of 5-fluorouracil; three main genetic polymorphisms of TS have been described. We analysed the prognostic value of these in patients with locally advanced rectal cancer treated with fluoropyrimidine-based chemoradiation. METHOD: Ninety-nine patients...

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Identifiers

PMID: 22958523
DOI: 10.1111/codi.12009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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