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Article

HBx mutations promote hepatoma cell migration through the Wnt/β-catenin signaling pathway.

Cancer science - 1 Oct 2016

Chen Zhen, Tang Jia, Cai Xuefei, Huang Yao, Gao Qingzhu, Liang Li, Tian Ling, Yang Yi, Zheng Yaqiu, Hu Yuan, Tang Ni

Abstract excerpt

HBx mutations (T1753V, A1762T, G1764A, and T1768A) are frequently observed in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Aberrant activation of the Wnt/β-catenin signaling pathway is involved in the development of HCC. However, activation of the Wnt/β-catenin signaling pathway by HBx mutants has not been studied in hepatoma cells or HBV-associated HCC samples. In this study, we examined the...

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Identifiers

PMID: 27420729
DOI: 10.1111/cas.13014
PMCID: PMC5084678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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