Article
Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses.
Carcinogenesis - 1 Jun 2008
Liu Xiaohong, Wang Li, Zhang Shuhui, Lin Jing, Zhang Shunmin, Feitelson Mark A, Gao Hengjun, Zhu Minghua
Abstract excerpt
BACKGROUND: The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx. METHODS: Genomic and proteomic expression profiling was performed in Huh7 HCC cells transfected with HBx mutants with a C-terminal deletion. The gene and protein expression of...
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