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Article

Molecular Mechanisms of HBV-Associated Hepatocarcinogenesis

8 Jun 2013

Abstract excerpt

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV-DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer-related genes. Prolonged expression of the viral regulatory protein HBx and the large envelope protein deregulate...

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PMID: 23749671
DOI: 10.1055/s-0033-1345721

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