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Article

Wnt Signaling in Liver Cancer

1 Nov 2008

Abstract excerpt

Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. As in many other types of cancer, aberrant activation of the canonical Wnt/beta-catenin signaling pathway is an important contributor to tumorigenesis. In HCC this frequently occurs through mutations in the N-terminal region of beta-catenin that stabilize the protein and permit an elevated level of constitutive transcriptional activation...

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PMID: 18991612
DOI: 10.2174/138945008786786127

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