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Article

Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 20 Sept 2016

Chen Rui, Rostami-Hodjegan Amin, Wang Haotian, Berk David, Shi Jun, Hu Pei

Abstract excerpt

PURPOSE: Determining metabolic ratio from single-point plasma is potentially a good phenotyping method of CYP2D6 to reduce the required time interval and increase the reliability of data. It is difficult to conduct large sample size clinical trials to evaluate this phenotyping method for multiple plasma points. A physiologically based pharmacokinetic (PBPK) model can be developed to do simulations based on the...

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Identifiers

PMID: 27412587
DOI: 10.1016/j.ejps.2016.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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