Article
Novel single-point plasma or saliva dextromethorphan method for determining CYP2D6 activity.
The Journal of pharmacology and experimental therapeutics - 1 Jun 1998
Hu O Y, Tang H S, Lane H Y, Chang W H, Hu T M
Abstract excerpt
O-Demethylation of dextromethorphan co-segregates with 4-hydroxylation of debrisoquin and is used for CYP2D6 phenotyping. In most previous studies, 8-h urinary samples were collected for determining the dextromethorphan metabolic ratio (dextromethorphan/dextrorphan molar ratio). In addition, a sa...
Topics
- Adult
- Antitussive Agents
- Area Under Curve
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6
- Dextromethorphan
- Dextrorphan
- Excitatory Amino Acid Antagonists
- Humans
- Male
- Phenotype
- Saliva