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Article

Gray matter maturation and cognition in children with different APOE ε genotypes.

Neurology - 9 Aug 2016

Chang Linda, Douet Vanessa, Bloss Cinnamon, Lee Kristin, Pritchett Alexandra, Jernigan Terry L, Akshoomoff Natacha, Murray Sarah S, Frazier Jean, Kennedy David N, Amaral David G, Gruen Jeffrey, Kaufmann Walter E, Casey B J, Sowell Elizabeth, Ernst Thomas

Abstract excerpt

OBJECTIVE: The aims of the current study were to determine whether children with the 6 different APOE ε genotypes show differences in gray matter maturation, particularly for those with ε4 and ε2 alleles, which are associated with poorer outcomes in many neurologic disorders. METHODS: A total of 1,187 healthy children (aged 3-20 years, 52.1% boys, 47.9% girls) with acceptable data from the cross-sectional...

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Identifiers

PMID: 27412137
DOI: 10.1212/WNL.0000000000002939
PMCID: PMC4977368

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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