Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Fennema-Notestine Christine, Panizzon Matthew S, Thompson Wesley R, Chen Chi-Hua, Eyler Lisa T, Fischl Bruce, Franz Carol E, Grant Michael D, Jak Amy J, Jernigan Terry L, Lyons Michael J, Neale Michael C, Seidman Larry J, Tsuang Ming T, Xian Hong, Dale Anders M, Kremen William S

Abstract excerpt

The presence of an ApoE ε4 allele (ε4+) increases the risk of developing Alzheimer's disease (AD). Previous studies support an adverse relationship between ε4+ status and brain structure and function in mild cognitive impairment and AD; in contrast, the presence of an ε2 allele may be protective. Whether these findings reflect disease-related effects or pre-existing endophenotypes, however, remains unclear. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Brain Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Mapping

Share to Frontal Lobe

Share to Functional Laterality

Share to Image Processing, Computer-Assisted

Share to Twin Studies as Topic

Share to Vietnam

Source

Open in PubMed Open full text

Identifiers

PMID: 21971450
DOI: 10.3233/JAD-2011-0002
PMCID: PMC3302177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age.PMID 21971450Read ↗

APOE4-related differences in cortical thickness are modulated by sex in middle age.Semantic proximity Read ↗

Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study.Semantic proximity Read ↗

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.Semantic proximity Read ↗

A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.Semantic proximity Read ↗

Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.Semantic proximity Read ↗

Differential effects of the ApoE4 genotype on brain structure and function.Semantic proximity Read ↗

The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults.Semantic proximity Read ↗

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s diseaseSemantic proximity Read ↗

A comprehensive analysis of <i>APOE</i> genotype effects on human brain structure in the UK BiobankSemantic proximity Read ↗

Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample.Semantic proximity Read ↗

The APOE ε4 allele in relation to brain white-matter microstructure in adulthood and aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.