Article
Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.
Translational psychiatry - 27 May 2014
Douet V, Chang L, Pritchett A, Lee K, Keating B, Bartsch H, Jernigan T L, Dale A, Akshoomoff N, Murray S, Bloss C, Kennedy D N, Amaral D, Gruen J, Kaufmann W E, Casey B J, Sowell E, Ernst T
Abstract excerpt
The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic and bipolar disorders. The rs6994992 variant in the NRG1 promoter (SNP8NRG243177) is associated with altered frontal and temporal brain macrostructures and/or altered white matter density and integrity in schizophrenic adults, as well as healthy adults and neonates. However, the ages when these changes begin and...
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