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Article

Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study.

JAMA neurology - 1 Jan 2014

Dean Douglas C, Jerskey Beth A, Chen Kewei, Protas Hillary, Thiyyagura Pradeep, Roontiva Auttawat, O'Muircheartaigh Jonathan, Dirks Holly, Waskiewicz Nicole, Lehman Katie, Siniard Ashley L, Turk Mari N, Hua Xue, Madsen Sarah K, Thompson Paul M, Fleisher Adam S, Huentelman Matthew J, Deoni Sean C L, Reiman Eric M

Abstract excerpt

IMPORTANCE: Converging evidence suggests brain structure alterations may precede overt cognitive impairment in Alzheimer disease by several decades. Early detection of these alterations holds inherent value for the development and evaluation of preventive treatment therapies. OBJECTIVE: To compare magnetic resonance imaging measurements of white matter myelin water fraction (MWF) and gray matter volume (GMV) in...

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Identifiers

PMID: 24276092
DOI: 10.1001/jamaneurol.2013.4544
PMCID: PMC4056558

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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