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Article

Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H).

Cancer cell - 11 Jul 2016

Somerville Tim D D, Vakoc Christopher R

Abstract excerpt

In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A(R882H)/NRAS(G12D) acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.

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Source

Identifiers

PMID: 27411582
DOI: 10.1016/j.ccell.2016.06.018

Genes

NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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