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Article

DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming.

Journal of translational medicine - 18 Jul 2023

Yang Xuejiao, Wang Xiao, Yang Ying, Li Zhiyang, Chen Yunshuo, Shang Siqi, Wang Yueying

Abstract excerpt

BACKGROUND: DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogenesis through hypomethylation of some target genes associated with cell growth and differentiation. In this study, we investigated the function of DNMT3A R882H in the malignant progression of AML...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37464424
DOI: 10.1186/s12967-023-04323-z
PMCID: PMC10355022

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