Article
Targeting AML at the intersection of epigenetics and signaling.
Science signaling - 19 Apr 2022
Narayan Nisha, Huntly Brian J P
Abstract excerpt
Mutations in multiple cancers may synergize to alter the cellular epigenetic and transcriptional state and corrupt key signaling pathways. In this issue of Science Signaling, Pedicona et al. illustrate how the two processes intersect to regulate cellular differentiation in acute myeloid leukemia (AML) and show how inhibition of epigenetic regulators promotes sensitivity to kinase inhibitors.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.