Article
Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.
Cell metabolism - 12 Jul 2016
Gitschlag Bryan L, Kirby Cait S, Samuels David C, Gangula Rama D, Mallal Simon A, Patel Maulik R
Abstract excerpt
Mutant mitochondrial genomes (mtDNA) can be viewed as selfish genetic elements that persist in a state of heteroplasmy despite having potentially deleterious metabolic consequences. We sought to study regulation of selfish mtDNA dynamics. We establish that the large 3.1-kb deletion-bearing mtDNA variant uaDf5 is a selfish genome in Caenorhabditis elegans. Next, we show that uaDf5 mutant mtDNA replicates in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.