Article

Germline mitophagy selectively eliminates deleterious mitochondrial DNA across generations

2026-06-25

Abstract excerpt

Faithful transmission of genetic information through the immortal germline is essential for organismal health and species survival, yet how mutant mitochondrial genomes (mtDNAs) are selectively eliminated across generations remains unclear. Here, we show that germline mitophagy functions as a mutation-responsive surveillance system that selectively eliminates mutant mtDNAs and shapes inheritance across generations...

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Literature Corpus work: 1014d623-0f3f-50d3-abfa-4d9c67ddebe4
DOI: 10.64898/2026.06.24.734151

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