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Regulation of defective mitochondrial DNA accumulation and transmission in <i>C. elegans</i> by the programmed cell death and aging pathways

2021-10-28

Abstract excerpt

The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). “Purifying selection” mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell death (PCD), including the CED-3 and CSP-1 caspases, the BH3-only protein CED-13, and PCD corpse engulfment factors, are required in C. elegans to attenuate germline abundanc...

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Literature Corpus work
9aacf03f-de25-5067-b23d-7324263763a9
DOI
10.1101/2021.10.27.466108
Open publication

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Regulation of defective mitochondrial DNA accumulation and transmission in <i>C. elegans</i> by the programmed cell death and aging pathwaysDOI 10.1101/2021.10.27.466108
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