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Article

Multiple distinct evolutionary mechanisms govern the dynamics of selfish mitochondrial genomes in Caenorhabditis elegans.

Nature communications - 19 Sept 2024

Gitschlag Bryan L, Pereira Claudia V, Held James P, McCandlish David M, Patel Maulik R

Abstract excerpt

Cells possess multiple mitochondrial DNA (mtDNA) copies, which undergo semi-autonomous replication and stochastic inheritance. This enables mutant mtDNA variants to arise and selfishly compete with cooperative (wildtype) mtDNA. Selfish mitochondrial genomes are subject to selection at different levels: they compete against wildtype mtDNA directly within hosts and indirectly through organism-level selection....

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Identifiers

PMID: 39300074
DOI: 10.1038/s41467-024-52596-9
PMCID: PMC11413162

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