Article

Tissue-specific heteroplasmy dynamics is accompanied by a sharp drop in mtDNA copy number during development

2021-07-31

Abstract excerpt

Mitochondrial mutation phenotypes are highly unpredictable as they depend on 3 variables; mutant-to-wildtype ratio (heteroplasmy level), total number of mitochondrial genomes (mtDNA), and the tissue affected. The exact phenotype experienced is governed by the combination of these variables, but current models lack the capability to examine the three variables simultaneously. We have established a C. elegans muscl...

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Literature Corpus work: a9142c56-9445-5af4-8c19-5d2d5bfd4283
DOI: 10.1101/2021.07.30.454495

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