Article
Stable heteroplasmy but differential inheritance of a large mitochondrial DNA deletion in nematodes.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2002
Tsang William Y, Lemire Bernard D
Abstract excerpt
Many human mitochondrial diseases are associated with defects in the mitochondrial DNA (mtDNA). Mutated and wild-type forms of mtDNA often coexist in the same cell in a state called heteroplasmy. Here, we report the isolation of a Caenorhabditis elegans strain bearing the 3.1-kb uaDf5 deletion that removes 11 genes from the mtDNA. The uaDf5 deletion is maternally transmitted and has been maintained for at least...
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