Article

Mutant <i>C. elegans</i> mitofusin leads to selective removal of mtDNA heteroplasmic deletions at different rates across generations

2019-04-16

Abstract excerpt

Deleterious and intact mitochondrial DNA (mtDNA) mutations frequently co-exist (heteroplasmy). Such mutations likely survive and are inherited due to complementation via the intra-cellular mitochondrial network. Hence, we hypothesized that compromised mitochondrial fusion would hamper such complementation, thereby affecting heteroplasmy inheritance. To test this hypothesis, we assessed heteroplasmy levels in three...

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Literature Corpus work: 53a147bd-6fef-550f-aaef-b80e39a188e4
DOI: 10.1101/610758

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