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Article

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.

Human molecular genetics - 15 Nov 2012

Lee Seungmin, Sterky Fredrik H, Mourier Arnaud, Terzioglu Mügen, Cullheim Staffan, Olson Lars, Larsson Nils-Göran

Abstract excerpt

Mitochondrial dysfunction is implicated in aging and degenerative disorders such as Parkinson's disease (PD). Continuous fission and fusion of mitochondria shapes their morphology and is essential to maintain oxidative phosphorylation. Loss-of-function mutations in PTEN-induced kinase1 (PINK1) or Parkin cause a recessive form of PD and have been linked to altered regulation of mitochondrial dynamics. More...

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Source

Identifiers

PMID: 22914740
DOI: 10.1093/hmg/dds352

Genes

PINK1
PTEN

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.PMID 22914740Read ↗

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.Semantic proximity Read ↗

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.Semantic proximity Read ↗

Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome RecruitmentSemantic proximity Read ↗

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neuronsSemantic proximity Read ↗

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiencySemantic proximity Read ↗

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune responseSemantic proximity Read ↗

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Semantic proximity Read ↗

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged miceSemantic proximity Read ↗

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagySemantic proximity Read ↗

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.Semantic proximity Read ↗

Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression.Semantic proximity Read ↗

Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo.Semantic proximity Read ↗

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