Article

The role of FBXO7 in mitochondrial biology and Parkinson's disease

2018-01-01

Abstract excerpt

Parkinson's disease is a progressive neurodegenerative disorder of the central nervous system, manifesting with both motor and non-motor symptoms. Autosomal recessive mutations in the FBXO7 gene have been identified to cause a rapidly progressing early-onset form of PD. Canonically, FBXO7 functions as a substrate-recruiting subunit of the SCF-type E3 ubiquitin ligase. However, it also has a variety of other atypic...

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Literature Corpus work: 1af45d29-deb8-57aa-b8ce-0d30fcc6cb10
DOI: 10.17863/cam.30350

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