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Article

Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice

14 Jun 2022

Abstract excerpt

Abstract Parkinson’s disease, the second most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons. FBXO7 (F-box protein only 7) (PARK15) mutations cause early-onset Parkinson’s disease. FBXO7 is a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex, but its neuronal relevance and function have not been elucidated. To determine its function in...

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PMID: 35701754
DOI: 10.1186/s13041-022-00936-5

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