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Article

Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children With Insulin Resistance.

Journal of clinical pharmacology - 1 Feb 2017

Sam Wai Johnn, Roza Orsolya, Hon Yuen Yi, Alfaro Raul M, Calis Karim A, Reynolds James C, Yanovski Jack A

Abstract excerpt

Steady-state population pharmacokinetics of a noncommercial immediate-release metformin (hydrochloride) drug product were characterized in 28 severely obese children with insulin resistance. The concentration-time profiles with double peaks were well described by a 1-compartment model with 2 absorption sites. Mean population apparent clearance (CL/F) was 68.1 L/h, and mean apparent volume of distribution (V/F)...

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Source

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Identifiers

PMID: 27407018
DOI: 10.1002/jcph.796
PMCID: PMC5233569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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