Article
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
Diabetes - 1 Jun 2009
Zhou Kaixin, Donnelly Louise A, Kimber Charlotte H, Donnan Peter T, Doney Alex S F, Leese Graham, Hattersley Andrew T, McCarthy Mark I, Morris Andrew D, Palmer Colin N A, Pearson Ewan R
Abstract excerpt
OBJECTIVE: Metformin is actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1). In 12 normoglycemic individuals, reduced-function variants in SLC22A1 were shown to decrease the ability of metformin to reduce glucose excursion in response to oral glucose. We assessed the effect of two common loss-of-function polymorphisms in SLC22A1 on metformin response in a large cohort...
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