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Influence of Solute Carrier Family 22 Member 1 (SLC22A1) Gene Polymorphism on Metformin Pharmacokinetics and HbA1c Levels: A Systematic Review.

Current diabetes reviews - 1 Jan 2024

Pradana A D, Kristin E, Nugrahaningsih D A A, Nugroho A K, Pinzon R T

Abstract excerpt

BACKGROUND: Solute Carrier Family 22 Member 1 (SLC22A1, also known as OCT1) protein has a vital role in the metabolism of metformin, a first-line anti-diabetes medication. Genetic poly-morphism in SLC22A1 influences individual response to metformin. OBJECTIVE: This review aims to compile the current knowledge about the effects of SLC22A1 genetic polymorphism on metformin pharmacokinetics and HbA1c levels....

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Identifiers

PMID: 37550919
DOI: 10.2174/1573399820666230807145202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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