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Impact of SLC22A1 variants rs622342 and rs72552763 on HbA1c and metformin plasmatic concentration levels in patients with type 2 diabetes mellitus

17 Jun 2024

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is a major global health problem. Response to first‑line therapy is variable. This is partially due to interindividual variability across those genes codifying transport, metabolising, and drug activation proteins involved in first‑line pharmacological treatment. Single nucleotide polymorphisms (SNPs) of genes SLC22A1, SLC22A2 and SLC22A3 affect metformin therapeutic response in...

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PMID: 38938740
DOI: 10.3892/br.2024.1806

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