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Article

Mitochondrial double-stranded RNA triggers antiviral signalling in humans.

Nature - 1 Aug 2018

Dhir Ashish, Dhir Somdutta, Borowski Lukasz S, Jimenez Laura, Teitell Michael, Rötig Agnès, Crow Yanick J, Rice Gillian I, Duffy Darragh, Tamby Christelle, Nojima Takayuki, Munnich Arnold, Schiff Manuel, de Almeida Claudia Ribeiro, Rehwinkel Jan, Dziembowski Andrzej, Szczesny Roman J, Proudfoot Nicholas J

Abstract excerpt

Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic features such as a compact circular genome. Consequently, in mammals, mitochondrial DNA is subjected to bidirectional transcription that generates overlapping transcripts, which are capable of forming long double-stranded RNA structures1,2. However, to our knowledge, mitochondrial double-stranded RNA has not been previously...

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Share to Interferon Type I
Share to bcl-2-Associated X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to bcl-2 Homologous Antagonist-Killer Protein

Share to Exoribonucleases

Share to Interferon-Induced Helicase, IFIH1

Share to Polyribonucleotide Nucleotidyltransferase

Share to RNA, Double-Stranded

Share to RNA, Mitochondrial

Source

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Identifiers

PMID: 30046113
DOI: 10.1038/s41586-018-0363-0
PMCID: PMC6570621

Genes

PNPT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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