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Article

Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2016

Rovaris Diego L, Aroche Angelita P, da Silva Bruna S, Kappel Djenifer B, Pezzi Júlio C, Levandowski Mateus L, Hess Adriana R B, Schuch Jaqueline B, de Almeida Rosa M M, Grassi-Oliveira Rodrigo, Bau Claiton H D

Abstract excerpt

Crack cocaine addicted inpatients that present more severe withdrawal symptoms also exhibit higher rates of depressive symptoms. There is strong evidence that the identification of genetic variants in depression is potentialized when reducing phenotypic heterogeneity by studying selected groups. Since depression has been associated to dysregulation of the hypothalamic-pituitary-adrenal axis, this study evaluated...

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Source

Identifiers

PMID: 27397864
DOI: 10.1016/j.euroneuro.2016.06.010

Genes

CRHR1
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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