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Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use.

Addiction biology - 1 Jul 2019

Schote Andrea B, Jäger Kristina, Kroll Sara L, Vonmoos Matthias, Hulka Lea M, Preller Katrin H, Meyer Jobst, Grünblatt Edna, Quednow Boris B

Abstract excerpt

Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As the glucocorticoid receptor gene (NR3C1) mediates genomic effects of the stress hormone...

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PMID: 29761890
DOI: 10.1111/adb.12632

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