Article
MR and GR functional SNPs may modulate tobacco smoking susceptibility.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Oct 2013
Rovaris Diego L, Mota Nina R, de Azeredo Lucas A, Cupertino Renata B, Bertuzzi Guilherme P, Polina Evelise R, Contini Verônica, Kortmann Gustavo L, Vitola Eduardo S, Grevet Eugenio H, Grassi-Oliveira Rodrigo, Callegari-Jacques Sidia M, Bau Claiton H D
Abstract excerpt
A number of studies have demonstrated that stress is involved in all aspects of smoking behavior, including initiation, maintenance and relapse. The mineralocorticoid (MR) and glucocorticoid (GR) receptors are expressed in several brain areas and play a key role in negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis. As nicotine increases the activation of the HPA axis, we wondered if functional...
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