A Landscape of Pharmacogenomic Interactions in Cancer.

doi:10.1016/j.cell.2016.06.017

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Article

A Landscape of Pharmacogenomic Interactions in Cancer.

Cell - 28 Jul 2016

Iorio Francesco, Knijnenburg Theo A, Vis Daniel J, Bignell Graham R, Menden Michael P, Schubert Michael, Aben Nanne, Gonçalves Emanuel, Barthorpe Syd, Lightfoot Howard, Cokelaer Thomas, Greninger Patricia, van Dyk Ewald, Chang Han, de Silva Heshani, Heyn Holger, Deng Xianming, Egan Regina K, Liu Qingsong, Mironenko Tatiana, Mitropoulos Xeni, Richardson Laura, Wang Jinhua, Zhang Tinghu, Moran Sebastian, Sayols Sergi, Soleimani Maryam, Tamborero David, Lopez-Bigas Nuria, Ross-Macdonald Petra, Esteller Manel, Gray Nathanael S, Haber Daniel A, Stratton Michael R, Benes Cyril H, Wessels Lodewyk F A, Saez-Rodriguez Julio, McDermott Ultan, Garnett Mathew J

Abstract excerpt

Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, we report how cancer-driven alterations identified in 11,289 tumors from 29 tissues (integrating somatic mutations, copy number alterations, DNA methylation, and gene expression) can be mapped...

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Identifiers

PMID: 27397505
DOI: 10.1016/j.cell.2016.06.017
PMCID: PMC4967469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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